Lietuvos mokslų akademijos tikroji narė (Biologija, 2014 m.)

Gimė 1959 01 02

Darbovietė

Lietuvos sveikatos mokslų universiteto Neuromokslų instituto vyriausioji mokslo darbuotoja, direktoriaus pavaduotoja, Biochemijos katedros profesorė

Išsilavinimas:

Vilniaus universitetas, Chemijos fakultetas, biochemijos specialybė, 1982

Gamtos mokslų daktarė, 1991

Svarbiausios publikacijos:

1. Morkuniene R, Cizas P, Jankeviciute S, Petrolis R, Arandarcikaite O, Krisciukaitis A, Borutaite V. Small Aβ1-42 oligomer-induced membrane depolarization of neuronal and microglial cells: Role of N-methyl-D-aspartate receptors. J Neurosci Res. 2014 
2. Morkuniene R., Zvirbliene A., Dalgediene I., Cizas P., Jankeviciute S., Jokubka R., Jankunec M., Valincius G., Borutaite V. Antibodies to Ab oligomers potentiate the neurotoxicity of Ab by activating microglia. J. Neurochem. 2013, 126(5):604-15
3. Borutaite V, Toleikis A, Brown GC. In the eye of the storm: mitochondrial damage during heart and brain ischaemia. FEBS J. 2013, 280: 4999-5014.
4. Brown GC, Borutaite V. There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells. Mitochondrion. 2012, 12(1): 1-4.
5. Borutaite V. Mitochondria as decision-makers in cell death. Eviron. Mol. Mutagen. 2010, 51: 406-416.
6. Cizas P., Budvytyte R., Morkuniene R., Moldovan R., Broccio M., Lösche M., Niaura G., Valincius G., Borutaite V. Size-dependent neurotoxicity of b-amyloid oligomers. Arch. Biochem. Biophys. 2010; 496: 84–92. 
7.  Borutaite V., Brown G.C. Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state. J Biol Chem. 2007, 282: 31124-31130.
8. Brown G.C., Borutaite V. Nitric oxide and mitochondrial respiration in the heart. Cardiovasc. Res. 2007, 75(2): 283-290.
9. Brown G.C., Borutaite V. Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols. Biochim. Biophys. Acta (Bioenergetics) 2004, 1658: 44-49.
10. Borutaite V., Brown G.C. Mitochondria in apoptosis of ischemic heart. FEBS Lett. 2003, 541: 1-5.
11. Borutaite V., Jekabsone A., Morkuniene R., Brown G.C. Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia. J. Mol. Cell. Cardiol. 2003, 35: 357-366.
12. Brown G.C., Borutaite V. Nitric oxide inhibition of mitochondrial respiration and its role in cell death. Free Radic Biol Med. 2002; 33(11):1440-1450(labiausiai cituojamas).
13. Tolkovsky AM, Xue L, Fletcher GC, Borutaite V. Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease? Biochimie. 2002; 84(2-3):233-40.
14. Borutaite V, Budriunaite A, Brown GC. Reversal of nitric oxide-, peroxynitrite- and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiols. Biochim Biophys Acta. 2000; 1459(2-3):405-12.
15. Brown GC, Borutaite V.  Nitric oxide, cytochrome c and mitochondria. Biochem Soc Symp. 1999; 66:17-25.